Three-dimensional (3D) brain microphysiological system for organophosphates and neurochemical agent toxicity screening
نویسندگان
چکیده
منابع مشابه
Human Vascular Microphysiological System for in vitro Drug Screening.
In vitro human tissue engineered human blood vessels (TEBV) that exhibit vasoactivity can be used to test human toxicity of pharmaceutical drug candidates prior to pre-clinical animal studies. TEBVs with 400-800 μM diameters were made by embedding human neonatal dermal fibroblasts or human bone marrow-derived mesenchymal stem cells in dense collagen gel. TEBVs were mechanically strong enough to...
متن کاملHuman iPSC-based Cardiac Microphysiological System For Drug Screening Applications
Drug discovery and development are hampered by high failure rates attributed to the reliance on non-human animal models employed during safety and efficacy testing. A fundamental problem in this inefficient process is that non-human animal models cannot adequately represent human biology. Thus, there is an urgent need for high-content in vitro systems that can better predict drug-induced toxici...
متن کاملInstrumented cardiac microphysiological devices via multimaterial three-dimensional printing
Biomedical research has relied on animal studies and conventional cell cultures for decades. Recently, microphysiological systems (MPS), also known as organs-on-chips, that recapitulate the structure and function of native tissues in vitro, have emerged as a promising alternative. However, current MPS typically lack integrated sensors and their fabrication requires multi-step lithographic proce...
متن کامل"3D-PP": Three-Dimensional Visual Programming System
Our research group [1] is doing research in the field of visual programming. We are interested in threedimensional visual programming environment in particular. The conventional visual programming systems mainly focused on two-dimensional pictorial programming. A big problem is that two-dimensional visual programming systems fail to manage a lot of pictorial programming elements. This paper pro...
متن کاملEvaluation of a fast method of EPID-based dosimetry for IMRT and Comparison with 3D EPID-based dosimetry system using conventional two- and three-dimensional detectors for VMAT
Introduction: Electronic portal imaging devices (EPIDs) could potentially be useful for intensity-modulated radiation therapy (IMRT) and VMAT QA. The data density, high resolution, large active area, and efficiency of the MV EPID make it an attractive option. However, EPIDs were designed as imaging devices, not dosimeters, and as a result they do not inherently measure dose in ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLOS ONE
سال: 2019
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0224657